Double pharmaceutical formula preaching promising results in wound healing health

Researchers have tested a new compound treatment that can eliminate difficult bacteria that inhabits chronic wounds. Their results highlight the ways to develop more effective antimicrobial treatments that enhance chronic wound healing.

These treatments can also help reduce the risk of severe infection that may sometimes lead to amputation, such as sugary foot ulcers.

The study was conducted by researchers from the University of Oregon in the United States, and its results were published on September 29 in the Journal of Applied and Environmental Biology, and the Yurrick Alert website was written about.

Collecting the approach that the study followed between materials known for a long time, which does not work on its own in combating difficult pathogens, which is exacerbated in chronic wounds, which is the pseudo -bacterial bacteria. But by adding small doses of a simple molecule called chlorine to standard antibiotics, this mixture has proven to be the effectiveness of bacterial cells in the laboratory 10,000 times more than mono antibiotics, and this type of effectiveness has reduced the dose of the drug needed to eliminate the Zanagarian false.

Chlons are a simple compound that is not harmful to mammals and humans with its low doses. It transforms antibiotics from weak -performance substances into effective substances in killing bacteria in cells and mice models infected with diabetes.

Melanie Spereo, a assistant professor in biology at the Faculty of Arts and Science at Oregon University and the main author of the study, said that if these results can be applied to humans, it may help shorten patients’ eating of antibiotics and reduce the risk of side effects.

Challenges of treating chronic wound infections

The chronic wound is an infected tissue that has not begun to recover during the natural time frames ranging from 4 weeks and 12 weeks.

Melanie said that the most common type of sugary foot ulcers, an open sore on the bottom side of the foot that is formed as a result of poor blood circulation, prolonged pressure and lack of sensation.

According to an research published by the American Diabetes Association, one in every 4 people with type II diabetes are infected with an ulcer in the foot, and more than half of these cases are infected.

The changes in blood flow, the high demand for inflammatory cells on the oxygen, and the presence of bacteria in the site of the chronic wound are all factors that limit the access of oxygen to the tissues, which prevents them from healing.

The conditions of hypoxia are the problem that makes it difficult to fight bacterial infection as it reveals and carries antibiotics resistance.

When the location of the wound becomes limited oxygen, bacteria resort to breathing nitrates to obtain energy. Its growth slows in the absence of oxygen, but it remains alive and continues to spread.

The slow growth resulting of this leads to bacteria, especially pseudo -Zanagaria, to make it very tolerated for traditional antibiotics. Melanie explained that this is because many medications are classified based on their effectiveness in eliminating fast -growing bacteria.

She added that if the bacteria grow slowly, these antibiotics, which are often experienced only in oxygen -rich conditions, become ineffective at least when giving them alone.

Melanie said that when the antibiotics are combined with a small molecule called chlorine, it “strains the bacterial cell in a way that makes it very sensitive to antibiotics.”